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| Model | Years | Speeds | Drive Train | Trans Model |
| E-450 Super Duty | 1999-2004 | 4 Spd | RWD 5.4L V8, 6.8L V10, 7.3L V8 Turbo Diesel | 4R100 |
| E-450 Super Duty | 2004-2016 | 5 Spd | RWD 5.4L V8, 6.8L V10, 6.0L Turbo Diesel | 5R110W |
| E-450 Super Duty | 2016-2019 | 6 Spd | RWD 6.2L V8, 6.8L V10 | 6R140 |
| E-450 Super Duty | 2021-2026 | 6 Spd | RWD 7.3L V8 Turbo Diesel | 6R140 |